Episodes

In this episode of our Core Conversations series, we explore the critical role of MEF2C, a transcription factor that shapes early brain development and influences a wide range of neurological functions. This conversation unpa...

Core Conversations are revisited episodes from our archives that still stick with us and feel especially relevant, offering meaningful insight for families in the MEF2C community. In this Core Conversations episode of the MEF...

In this episode of MEF2Cast , we sit down with Helle and Andreas to share their family’s journey navigating life with MEF2C haploinsufficiency syndrome (MCHS). Helle reflects on the early signs that something was different, t...

In this episode, we sit down with Dr. Elizabeth Laughlin, PharmD, to explore the use of Leucovorin, a prescription form of folate, and its emerging role in supporting children with certain neurological and folate-related immu...

In this episode, we sit down with Sean Rafferty and Claire Bothwell to talk about the creation of the Australian foundation dedicated to supporting families affected by MEF2C haploinsufficiency syndrome (MCHS). Sean and Clair...

In this episode of the MEF2Cast , we sit down with Sean and Claire to talk openly about their journey raising their daughter, Thea, who has MEF2C haploinsufficiency syndrome (MCHS). Together, they share what it looks like to ...

In this episode, we sit down with siblings Maddie and Max Kelly as they reflect on what it was like growing up alongside their brother, Oscar, who has special needs. Through honest stories and heartfelt insight, they share ea...

In this episode, we sit down as hosts—and as parents—to reflect on the past nine months of life, learning, and growth with our son, Leo. We share a deeply personal update on his developmental journey, including the incredible...

In this episode, we sit down with Caroline Donnelly , a devoted mother who shares the deeply personal journey of receiving a life-changing diagnosis for her daughter, Jess. Caroline walks us through the moment she opened the ...

In this episode, we sit down with Caroline Donnelly , a devoted mother who shares the deeply personal journey of receiving a life-changing diagnosis for her daughter, Jess. Caroline walks us through the moment she opened the ...

In this episode, we sit down with Susan Simmons to revisit her family’s powerful journey with her son, Andrew, who has autism and MEF2C haploinsufficiency syndrome. Susan reflects on Andrew’s early development, the long road ...

In this episode, we sit down with Shawnacy and Cody Bruce, parents navigating the beautifully complex world of raising two daughters—one of whom, Boston, has developmental delays and CVI. With honesty, humor, and deep love, t...

In this episode of MEF2Cast , we sit down with Dr. Laurence Hurst, Professor of Evolutionary Genetics at the University of Bath, to explore how imperfection drives evolution. Dr. Hurst breaks down the fundamentals of Darwinia...

In today’s episode, we are joined by Dr. Tim O’Sullivan, a immunologist at UCLA, as well as his graduate student Cassidy Lee. Dr. O’Sullivan and Cassidy join us to discuss the emerging research on MEF2C’s role in immune funct...

In this episode, we sit down with Mariah and Adam Zwick to discuss their journey raising Noah — a bright and determined little boy with a rare genetic condition. Mariah and Adam open up about the earliest signs that something...

In this episode, we dive into the promising world of gene therapy with Dr. Steven Gray from the University of Texas Southwestern and Caroline Claflin, co-founder of the MEF2C Family Foundation. Dr. Gray shares his two-decade ...

In this episode, we sit down with Erica Anderson , a Board-Certified Behavior Analyst (BCBA), to explore the evolution of Applied Behavior Analysis (ABA) and how modern practices are shifting toward inclusivity, empathy, and ...

In today’s Core Conversations episode, we are joined by Sam Fox , Spelling to Communicate (S2C) practitioner and owner of Beyond Speech Therapy Center in Munroe Falls, OH. Sam joins us to discuss spelling as a means of commun...

In this first installment of our Core Conversations series, we explore the critical role of MEF2C , a transcription factor that shapes early brain development and influences a wide range of neurological functions. This conver...

Episode 24: Autism and Movement with Sheena Leedham In this episode, we sit down with Sheena Leedham, an educator and trainer whose work highlights the power of movement in the autism community. Sheena shares her unexpected j...

In this episode of the MEF2Cast, Blake Kelly shares her personal journey of raising her son Oscar, who has MCHS. She discusses the challenges of navigating healthcare in Amsterdam compared to the U.S., the emotional rollercoa...

In this episode, we sit down with Dr. Zachary Grinspan, a pediatric neurologist whose work focuses on MEF2C haploinsufficiency syndrome (MCHS). Dr. Grinspan leads the Volāre study , a groundbreaking effort to map the natural ...

In this episode, we sit down with Kristina Johnson, a professor at Northeastern University and mother to her son Felix, who was diagnosed with MEF2C haploinsufficiency syndrome at just nine months old. Kristina shares her fam...

In this episode, we sit down with Jennifer and Kieth Aguirre , parents to their daughter Maddie, who has MEF2C haploinsufficiency syndrome. The Aguirres share their family’s journey — from the long road to diagnosis, to reloc...